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KMID : 0882419940470040503
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Korean Journal of Medicine
1994 Volume.47 No. 4 p.503 ~ p.509
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Evaluation of Diagnostic Value of Ammonia Concentration in Gastric Juice for Helicobacter pylori Gastritis
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한상영
손지원/정원태/최석렬/신우원
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Abstract
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Objectives:
@EN Helicobacter pylori is reportedly related to gastroduodenal damage. But, the mechanism for H. pylori induced gastric mucosal injury remains obscure. H. pylori has high urease activity to produce ammonia from urea in stomach.
@ES Methods:
@EN In this sudy, we evaluated the cut-off value of gastric ammonia in basis of Giemasa stain and relationships of ammonia and urea nitorgen between in gastric juice and in serum. We also evaluated usefulness of diagnostic method of gastric
ammonia
test
according to cut-off value in basis of Giemsa stain on chronic gastritis (n=50). And we compared gastric ammonia test with rapid urease test (CLO test).
@ES Results:
@EN 1) Thiry-one patients (62%) had H. pylori identifiable in Giemsa stain.
2) The ammonia concentration of gastric juice was significantly higher in H. pylori-infected gastritis than in H. pylori-negative gastritis (61.76±43.0 vs 20.96±17.77mmol/dl, p<0.001).
3) There were no statistical differences between ammonia and urea nitrogen in gastric juice and in serum.
4) Cut-off value of gastric ammonia concentration according to Giemsa stain was 7.78mmol/dl(Ep sign test).
5) When we compared gastric ammonia test with rapid urease test (CLO test). the sensitivity of the methods were 100% vs 97%, and the specificity were 57% vs 95%, and probability were 79% vs 97%.
@ES Conclusion:
@EN The ammonia concentration of gastric juice is significantly higher in H. pylori-infected gastritis than H. pylori-negative gastritis and the gastric ammonia test in this study is useful in diagnosis of H. pylori infected gastritis.
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KEYWORD
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